It is strongly advised that you obtain malaria prophylactics before entering Mozambique and remember to complete the course as directed after leaving the malaria area. If you suffer from side effects, try taking your malaria prophylactics at night after dinner. Resistance to prophylactics (mainly those containing Chloroquine) is widespread so it is best to take precautionary measures to prevent contact with mosquitoes by using mosquito nets when sleeping.
You do not require inoculations for cholera, smallpox or yellow fever are required unless you are coming from an infected area. It is recommend that visitors should take precautions against yellow fever, tetanus, diphtheria, cholera, polio, typhoid, smallpox, malaria and hepatitis A, if you will be in the country for more than a couple of weeks. If you are staying in lodges or hotels that have a reliable supply of pure water you should not encounter these problems.